HMDEG is a searchable database for Human and Mouse Differentially Expressed Genes for easy query of genes that are differentilally expressed in specific tissues as determined by a statistical analysis of EST (expressed sequence tags) database (dbEST). We have organized the EST libraries into hierarchical tissue classes and identified preferentially expressed genes in 157 human and 108 mouse tissues/organs, from more than 8 million EST, characterized by their significantly different amount of transcripts observed between tissues.

Query differentially expressed genes of human or mouse

In this site, user can browse tissue-specific genes of human or mouse by selecting tissue and diseased sate, or query expression profile for genes in interest on the "Query" page. The default p value is set on 0.05 and can be set lower; for tissue-pecific genes, 90% are expressed in no more than 3 tissues as p<0.000001.

Search tissue-specific orthologous genes

Further, we comparatively analyzed expression profiles between 7854 orthologous pairs of human and mouse in 94 human and 99 mouse normal tissues. The tissue-specific orthologous genes are also available for query on the "Ortholog" page.

HMDEG was created by Sheng-Ying Pao and Chia-Chin Wu of the laboratory of Dr. Ming-Jing Hwang.

Latest update on: 07/22/2005